Researchers at Hokkaido University have discovered that cancer stem cells cause immune cells called macrophages to undergo senescence, leading to tumor growth. The team found that cancer stem cells produced a molecule called interleukin 6 (IL-6) that triggered this effect. They also found that supplementing mice with a molecule called nicotinamide mononucleotide prevented tumor growth and increased survival times by promoting the proliferation of non-senescent macrophages.
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